>>1509871>Perception and mind altering drugs are not 100% safe
The biggest obstacle to this is purity and sourcing. If you had pure LSD and took a low dosage then safety is very high. No more problematic or chance of side effects then what's available over the counter. Read the warnings on any generic drug, there's always a ton of fine print because individuals may react differently. No drug legal or illegal is "100% safe". In fact you could say the same about foods and risk of contaminations or allergic reaction. Not a fair metric.
Of course, being in certain environments will carry their own unique risks and considerations. I'm speaking purely about the pharmecology of said substances