Oh, fuck off.
This guy programmed the original GB games in fucking Assembly. Assembly is by far the most bullshit programming language you can think of, and he wrote an entire game using it. I can't imagine how many sleepless nights that took.
Game development is really fucking difficult, especially when you need to oversee literally everything and your game HAS to be good because it's a series loved by everyone in Japan. Japanese work environment is extremely stressful as it is, but his job is so fucking difficult that you would most likely go mad if you tried to do it. Did you watch New Game, that anime about game development? You remember those jokes about sleeping under your desk in the office? That's not a joke, that's what people like Matsuda actually do.
Bad teeth is by far the most innocent health problem you can get from that job.