1. Pokémon can disobey their trianers if they don't respect them. That usually happens with traded pokémon but Gen 3 Deoxys in particular hates your guts if you cheated.
2. Buneary evolve with max friendship/happiness. It's the only way to get Lopunny beside trades.
So either way, that comic makes no sense. Also... neither of those pokémon have breasts in official media, that makes the "artist" a hypocrite.