OP, as you can see from the responses given by the shitty little arseholes who make up the majority of this board, your chances of getting a real answer dwindle from astronomically low to the infinitesimal.
Personally I do not believe that infinitesimals exist. Nor infinity for that matter. But the concept, however erroneous, serves well to illustrate my point.
At this point, OP, I am of the opinion that no such game exists in any palatable form. But as something which points towards such a scenario as you described, in principle but not era, you could look at Sid Meier's Alpha Centurie. SMAC. Its a scifi version of Civ, That is if you asking for the sake of game development rather than just entertainment..
I do believe there is such a thread on this board now, if the hoi4 fuckwits haven't bumped it off into oblivion.