Not that anon, but yes. C2C in particular is infamous for basically being unplayable once you get into the later eras. That's why I'd rather stick with RoM: AND instead, since it's not that bloated and still has the stuff you'd want.
I'd also reccomend trying out Civ IV: Colonization. It's not as good as the DOS game, if you're familiar with the original, but mods can fix that issue. We the People, TAC, even some wilder ones like one that tries to move it out to the wild west or one that moves it into space and makes a new tech tree.