Ozarks has Ozark Highland Trail
Ouachitas has the Ouachita Trail
Both around 200 miles long, so you can pick a section you want to do.
there's also shorter trails 3-day loops like eagle rock loop, etc.
Ozark trail is more weaving in valleys of creeks and waterfalls
Ouachita trail is more top of ridge mountain overlooks (especially the part that parallels Talimena scenic drive)>Would it be worth the extra detour to Hot Springs NP
If you're in the Ouachitas they're a lot closer to hot springs NP
Keep in mind it's going to be november, so the trees will be barren and grey.
Plus thanksgiving is dead in the middle of deer season, and hunting's pretty big in Arkansas